Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AFAP1L2 contributors: mct - updated : 14-11-2016
HGNC name actin filament associated protein 1-like 2
HGNC id 25901
Location 10q25.3      Physical location : 116.054.583 - 116.164.515
Synonym symbol(s) XB130, KIAA1914, FLJ14564
DNA
TYPE functioning gene
STRUCTURE 124.41 kb     19 Exon(s)
MAPPING cloned   linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 splicing 4019 91 818 - 2007 17412687
19 splicing 4007 90 814 - 2007 17412687
- - 4178 - 871 - 2007 17412687
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver     Homo sapiens
Endocrinepancreas     Homo sapiens
 thyroid   predominantly Homo sapiens
Lymphoid/Immunespleen   highly Homo sapiens
Nervousbrain     Homo sapiens
Urinarykidney   highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus (167 AAs) and C-terminus (63 AAs) harbor crucial regions for its translocation to lamellipodia, whereas the PH domains and Src-targeted tyrosines are dispensable
  • two pleckstrin homology (PH) domains
  • several Src homology (SH)2- and SH3-binding motifs
  • a coiled-coil region
  • a number of potential tyrosine or serine/threonine phosphorylation sites
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Afap1l2 (83.1 pc)
    intraspecies homolog to actin-filament-associated protein AFAP1
    Homologene
    FAMILY
    CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may play an important role in the regulation of signal transduction and cellular functions
  • cytosolic adaptor protein and tyrosine kinase substrate, involved in Src- and RET/PTC-dependent signaling
  • exhibited robust translocation to the cell periphery in response to various stimuli (including epidermal growth factor, wounding and expression of constitutively active Rac) that elicit lamellipodium formation
  • Rac- and cytoskeleton-regulated and cytoskeleton-regulating adaptor protein that exhibits high affinity to lamellipodial (branched) F-actin and impacts motility and invasiveness of tumor cells
  • promotes thyroid tumor growth, and its expression in these cancer cells may affect cell proliferation and survival by controlling the expression of multiple genes, especially transcription regulators
  • could be involved in growth and survival of different cancer cells
  • adaptor protein involved in the regulation of cell proliferation, survival and migration
  • is potentially involved in the regulation of airway epithelial differentiation, especially during airway repair after injury
  • regulates cell growth, survival, and migration
  • can regulate cell growth, migration and invasion and possibly has the effect through the cAMP-SRC-phosphoinositide 3-kinase/AKT pathway
  • is required for airway epithelial repair and regeneration and interaction between AFAP1L2 and another scaffold protein, SH3PXD2A, regulates cell proliferation and survival in human bronchial epithelial cell
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SRC tyrosine kinase
  • is a substrate of multiple protein tyrosine kinases, and it can regulate cell proliferation and survival through modulating selected down-stream signals of PI3K/Akt pathway
  • physical interaction between TERF1 and AFAP1L2 proteins (this finding brings a novel piece of evidence for the emerging role of telomere dysfunction into melanoma development)
  • SH3PXD2A and AFAP1L2 interact endogenously and form a complex with SRC tyrosine kinase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate carcinoma with significantly decreased survival
    tumoral     --over  
    associated with a better survival in non-small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a possible prognostic indicator for prostate cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    potent therapeutic target for prostate cancer
    ANIMAL & CELL MODELS