basic FUNCTION
| playing an important role in enamel matrix formation and mineralization |
|
promotes cell binding through the heparin binding sites and plays an important role in preventing odontogenic tumor development by suppressing cell proliferation and maintaining differentiation phenotypethrough Msx2, p21 and p27 |
|
most abundant nonamelogenin enamel matrix protein, playing a role in ameloblast differentiation |
|
functions as a promoting factor for osteogenic differentiation via a novel pathway through the interaction between CD63 and ITGB1 |
|
increases osteoclast number and differentiation as well as mineralized tissue resorption by regulating cell adhesion and actin cytoskeleton polymerization, initiating integrin-dependent extracellular matrix signaling cascades and enhancing osteoclastogenesis |
|
plays a crucial role in the regulation of cranial bone growth and suture closure via MSX2 suppression and proliferation inhibition |
|
AMBN facilitates likely rapid long bone growth and an important growth spurt during the skeletogenesis of adolescent tooth-bearing vertebrates |
|
is critical for the initiation of enamel ribbon formation, and its absence results in pathological mineralization within the enamel organ epithelia |
|
TFIP11, AMBN, and AMELX play an important role in dental caries |