basic FUNCTION
| able to cooperate with MED1 to regulate estrogen receptor-mediated gene transcription |
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recruited, in a ligand-dependent manner, to endogenous estrogen receptor target gene promoters and is required for their expression |
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new MED1-interacting protein required for estrogen-dependent gene transcription and breast cancer cell growth |
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a role for ARGLU1 in estrogen receptor-mediated transcription in conjunction with MED1 |
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direct role for ARGLU1 in ER-mediated transcription on its target gene promoters |
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not only plays a key role in ER-mediated transcription but that it is also required for the growth, as well as both the anchorage-dependent and -independent colony formation of breast cancer cells |