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FLASH GENE
Symbol ARGLU1 contributors: mct/npt - updated : 11-01-2012
HGNC name arginine and glutamate rich 1
HGNC id 25482
Location 13q33.3      Physical location : 107.195.663 - 107.220.514
Synonym symbol(s) FLJ10154, DKFZp686O08106, RP11-297I6.1
DNA
TYPE functioning gene
STRUCTURE 24.85 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1772 33 273 - 2011 21454576
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumear   highly
Lymphoid/Immunethymus   highly
Nervousnerve   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly polarized protein enriched in positively charged amino acids at the first 98 N-terminal amino acids (27 arginine and 8 lysine) with the rest of the sequence highly enriched for negatively charged residues (49 Glutamate)
  • N-terminal 98 AAs of ARGLU1 are sufficient to interact with MED1 and associated Mediator subunits
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • colocalizes with MED1 in the nucleus, but also directly interacts with a far C-terminal region of MED1
  • basic FUNCTION
  • able to cooperate with MED1 to regulate estrogen receptor-mediated gene transcription
  • recruited, in a ligand-dependent manner, to endogenous estrogen receptor target gene promoters and is required for their expression
  • new MED1-interacting protein required for estrogen-dependent gene transcription and breast cancer cell growth
  • a role for ARGLU1 in estrogen receptor-mediated transcription in conjunction with MED1
  • direct role for ARGLU1 in ER-mediated transcription on its target gene promoters
  • not only plays a key role in ER-mediated transcription but that it is also required for the growth, as well as both the anchorage-dependent and -independent colony formation of breast cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MED1/Mediator-associated protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS