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FLASH GENE
Symbol ARID4A contributors: mct - updated : 28-10-2010
HGNC name AT rich interactive domain 4A (RBP1-like)
HGNC id 9885
Location 14q23.1      Physical location : 58.765.221 - 58.840.448
Synonym name
  • retinoblastoma binding protein 1
  • ARID domain-containing protein 4A
  • Synonym symbol(s) RBP1, RBBP1
    DNA
    TYPE functioning gene
    STRUCTURE 82.75 kb     27 Exon(s)
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • an ESR1 response element and a Sp1 site located within the first intron )
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 5585 - 1188 - 1999 10321733
    24 - 5792 - 1257 - 1999 10321733
    24 - 5630 - 1203 - 1999 10321733
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a rodlike tail sequence highly repetitive, composed of an heptapeptide repeat pattern characteristic of alpha-helical coiled coils
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • induces growth arrest by repression of E2F-dependent transcription
  • retinoblastoma cofactor involved in the control of osteoblastic proliferation
  • cancer metastasis suppressor 1 (BRMS1)
  • member of epigenetic complexes regulating genomic imprinting at the PWS/AS domain (Wu 2006)
  • potent coactivator of RUNX2 transcriptional activity, and expression and activity of RUNX2 is critically dependent on the presence of ARID4A
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with breast cancer metastasis suppressor 1 (BRMS1)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with p130-E2F and pRB-E2F complexes specifically during growth arrest
  • BRMS1 metastasis suppressor interacts with ARID4A, as part of SIN3.histone deacetylase chromatin remodeling complexes
  • regulating RUNX2 expression, regulation mediated through the proximal P2 RUNX2 promoter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Arid4a-deficient mice initially display ineffective hematopoiesis, followed by transition to chronic myelomonocytic leukemia (CMML)-like myelodysplastic/myeloproliferative disorder, and then transformation to AML