SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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text
| localize to kinetochores with MAD1L1 and MAD2L1 |
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localize to centrosome where it physically interacts with PLK1 |
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helps promote the establishment of stable kinetochore-microtubule attachments during prometaphase |
basic FUNCTION
| multidomain protein kinase playing an important role in cell division |
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modulating the timing of anaphase initiation in mitotic cells with improperly aligned chromosomes |
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contributing to a specific driving force in tumor metastasis and progression as a result of nonmutational, as well as mutational inactivation |
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playing a role in regulating aging and infertility |
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acting as a crucial meiotic timer, mediating a prophase delay in every meiosis |
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playing an essential role for early embryonic development and normal hematopoiesis |
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plays an essential role in kinetochore localization and assembly of other spindle assembly checkpoint components |
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plays an important role in the DNA damage response |
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having functions in the spindle checkpoint remarkably dosage-dependent and reduction of BUB1B expression resulting in premature chromatid separation and aneuploidy |
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may play an important role in mediating the cross-talk, between spindle checkpoint components and ERKs and MEK |
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involved in the mitotic spindle checkpoint pathway |
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at centrosome, inhibits PLK1 phosphorylation and its kinase activty during interphase, thus preventing centrosome reduplication |
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required for ubiquitin-mediated proteasomal degradation of CDC20 in the G0 phase and maintains anaphase-promoting complex/cyclosome-CDC20 homolog 1 activity that regulates the optimal level of dishevelled for ciliogenesis |
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cell cycle regulator, plays a crucial role in cilia formation through the quantitative regulation of ciliary protein |
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functions as a crucial component that monitors proper chromosome congression and mitotic timing during cell division |
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its sumoylation plays an important role in its timely removal from the kinetochores and the checkpoint inactivation, thus allowing normal anaphase entry and chromosome segregation |
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vertebrate mitotic checkpoint protein that is an unusual pseudokinase |
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counteracts AURKB activity at improperly attached kinetochores by recruiting B56-PP2A phosphatase complexes |
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critical component of the spindle assembly checkpoint, the surveillance mechanism that helps maintain the high fidelity of mitotic chromosome segregation by preventing cells from initiating anaphase if one or more kinetochores are not attached to the spindle |
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potentially contributes to enhanced polyploidization by a mechanism other than its spindle assembly checkpoint (SAC) function |
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MAD2L1 is one of the key components of the spindle and mitotic checkpoint complex that regulates the fidelity of cell division along with MAD1L1, CDC20, BUB1B |