SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,matrix
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,nucleus,nucleolus
|
text
| translocated to the nuceus upon mitogenic stimulation |
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predominantly localized to the mitochondrial matrix near the nucleoid associated with mitochondrial transcription factor A |
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close association with the mitoribosome |
basic FUNCTION
| pre-mRNA splicing factor SP2 p32 subunit, preventing exon skipping and regulating alternative splicing |
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putatively involved in nucleus-mitochondrion interactions |
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inhibition of C1 activation and complement-mediated lysis |
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endogenous substrate for MAP kinase involved cell death in a normal cellular environment |
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is a novel regulator of FOXC1-mediated transcription activation |
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its up-regulation might play an important role in the metastasis of breast cancer |
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appears to act as an endogenous inhibitor of the mitochondrial permeability transition pore, most likely through binding to PPIF, and thus protects cells against oxidative stress |
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is required for functional mitoribosome formation to synthesize proteins within mitochondria |
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critical contributions of C1QBP protein to the morphology of mitochondria and ER under normal cellular conditions, as well as important roles of this protein in cellular metabolism and various stress responses |
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the key C1QBP enhances the enzymatic efficiency of RNASEH1 |
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has roles in inflammation and infection processes, mitochondrial ribosome biogenesis, and regulation of apoptosis and nuclear transcription |