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FLASH GENE
Symbol CHDH contributors: mct - updated : 12-11-2014
HGNC name choline dehydrogenase
HGNC id 24288
Location 3p21      Physical location : 53.850.387 - 53.880.419
Synonym name Choline dehydrogenase, mitochondrial
EC.number 1.1.99.1
DNA
TYPE functioning gene
STRUCTURE 28.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,mitochondria,outer
intracellular,cytoplasm,organelle,membrane
text
  • found on both the outer and inner membranes of mitochondria in resting cells
  • basic FUNCTION
  • CHDH is required for PARK2-mediated mitophagy for the recruitment of SQSTM1 and MAP1LC3A onto the mitochondria for cargo recognition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CHDH is not a substrate of PARK2 but interacts with SQSTM1 independently of PARK2 to recruit SQSTM1 into depolarized mitochondria
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS