protein
| phosphorylating and inactivating CDC25C |
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mediating ATR, checkpoint inhibition of replication induction following UV induced DNA damage |
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interacting wih AURKB (phosphorylates Aurora-B and enhances its catalytic activity) |
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FBXO6 regulates CHEK1 stability and cellular sensitivity to replication stress |
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CLSPN acts synergistically with damaged DNA to increase phosphorylation of CHEK1 by ATR |
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interacting with FANCM (most likely contributes to CHEK1 and SMC1A phosphorylation by stimulating ATR activity towards its targets through promoting TOPBP1 retention on chromatin) |
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CLASPIN appears to be a master regulator of CHEK1 activity |
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CDC14B as a CHEK1 substrate (interplay between CHEK1 kinase and CDC14B phosphatase involving radiation-induced nucleolar shuttling to facilitate error-free cell cycle progression and prevent genomic instability) |
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CHEK1-mediated protection of replication forks from MUS81/EME1 even under otherwise unchallenged conditions is therefore vital to prevent uncontrolled fork collapse and ensure proper S-phase progression in human cells) |
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Claspin and RAD17 are reportedly involved in the DNA damage-induced phosphorylation of CHEK1, a hallmark of checkpoint activation |
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CHEK1 phosphorylation of SETMAR enhances DNA repair but inhibits replication fork restart |
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RPS6KA1 facilitates nuclear CHEK1 accumulation through CHEK1-Ser-280 phosphorylation and this pathway plays an important role in the preparation for monitoring genetic stability during cell proliferation |
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CHEK1 phosphorylates ERRFI1 on Ser 251, resulting in the inhibition of ERRFI1, and CHEK1 acts as a positive regulator of EGF signalling |
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CASP and non-CASP family proteases intricately regulate cleavage for up-regulation of CHEK1 kinase activity during programmed cell death |
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DTL targets the activated form of CHEK1 for destruction in the nucleoplasm rather than on chromatin and that this occurs in a PCNA-independent manner |
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WDR18 facilitates ATR-dependent CHEK1 phosphorylation via interacting with both C-terminus of TOPBP1 and CHEK1 |
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NEK1 is required for efficient CHEK1 activation in human cells |
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TICRR stimulates ATR phosphorylation of CHEK1 in a TOPBP1-dependent manner |
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after replication stress, the checkpoint kinase CHEK1 phosphorylates E2F6, leading to its dissociation from promoters, and this promotes E2F-dependent transcription, which mediates cell survival by preventing DNA damage and cell death |
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TLK1 and CHEK1 act in concert to modulate the phosphorylation status of RAD9A, which in turn serves to regulate the DNA damage response |
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CHEK1 is required for the metaphase-anaphase transition via regulating the subcellular localization and the expression of CDC20 and MAD2L1 |
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SETMAR decreases CHEK1 interaction with DDB1, and decreases CHEK1 ubiquitination |
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function of HERC2/USP20 in coordinating CHEK1 activation by modulating CLSPN stability, which ultimately promotes genome stability and suppresses tumor growth |
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APOBEC3A expression caused ATR-dependent phosphorylation of CHEK1 and cell-cycle arrest, consistent with replication checkpoint activation |
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HUWE1 plays a significant role in the regulation of the DNA damage repair (DDR) signaling pathway by directly modulating the abundance of CHEK1 protein |
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SMG7 is an indispensable signaling component in the ATR-CEHK1 pathway during genotoxic stress response |
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CTDNEP1 post-translationally modulates the activities of key regulators for chromosome segregation and mitotic checkpoint regulators including topoisomerase TOP2A and checkpoint kinase CHEK1 |