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FLASH GENE
Symbol CRNN contributors: - updated : 28-02-2006
HGNC name cornulin
HGNC id 1230
Location 1q21      Physical location : 152.381.718 - 152.386.750
Synonym name chromosome 1 open reading frame 10
Synonym symbol(s) PDRC1, C1orf10, SEP53
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
digestiveesophagus   specific
Digestivemouthtongue   
Reproductivefemale systemuteruscervix  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Amphiphilic
STRUCTURE
motifs/domains
transmembrane domain with two EF-hand calcium binding domains of 90 AA at the N terminus and a consecutive repeat of 60 AA,C terminus anchored in the outer plasma membrane
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Crnn
Homologene
FAMILY calcium-binding protein family
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • potential precursor protein of the cornified cell envelope
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS