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FLASH GENE
Symbol CUL9 contributors: mct - updated : 30-11-2011
HGNC name cullin 9
HGNC id 15982
Location 6p21.1      Physical location : 43.149.921 - 43.192.324
Synonym name
  • UbcH7-associated protein 1
  • p53-associated parkin-like cytoplasmic protein
  • Synonym symbol(s) H7AP1, PARC, RP3-330M21.2
    DNA
    TYPE functioning gene
    STRUCTURE 42.40 kb     41 Exon(s)
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    41 - 7771 - 2517 - 2011 21487039
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • critical regulator in controlling TP53 subcellular localization and subsequent function
  • CUL9-interacting peptides are promising candidates for the enhancement of TP53-dependent apoptosis in tumors with wild type cytoplasmic TP53
  • E3 ubiquitin ligase that binds to TP53 and localizes in the cytoplasm
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • intricate assembly of CUL9- and CUL7-containing complexes is highly regulated, and multiple subcomplexes may exhibit ubiquitin ligase activity
  • interaction with TP53 (function of CUL9 in tumor suppression is largely mediated by TP53)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS