basic FUNCTION
| acting as an inhibitor of Dsh-mediated signaling pathways during development |
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may stabililize the beta-catenin degradation complex by binding to DSH |
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required for normal vertebrate development |
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negatively modulates the basal activity of Wnt/CTNNB signaling in the nucleus by keeping LEF1 in the repressive state and controls Wnt/CTNNB signaling in both the cytoplasm and the nucleus |
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preadipocyte gene involved in the regulation of human adipogenesis |
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regulates adipogenesis through coordinated effects on gene expression that selectively alter intracellular and paracrine/autocrine components of the Wnt/beta-catenin signaling pathway |
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contributes to morphogenesis at the primitive streak by regulating VANGL2 upstream of cell adhesion and the PCP pathway |
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DACT1 and DACT3 may contribute to early tooth formation by modulation of Wnt signaling pathways in the mesenchyme, including preodontoblasts |
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can negatively modulate Wnt signaling by promoting DVL degradation in the cytoplasm and disrupting the CTNNB1·LEF1 complex in the nucleus |
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during neuronal differentiation, plays a critical role in a molecular pathway promoting Rac activity underlying the elaboration of dendrites and the establishment of spines and excitatory synapses |
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cytoplasmic regulator of intracellular signaling, inhibiting Wnt signaling |
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cytoplasmic protein expression was associated with tumor malignant progression via beta-catenin accumulation |
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conserved role for DACT proteins in kinase-regulated biochemistry involving VANGLl and DVL |
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principal role for all DACT family members is in the Planar Cell Polarity pathway (PCP) |
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DACT1 is an important positive regulator in colon cancer |
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SESTD1, DVL2 and DACT1 co-regulate the Wnt/Planar Cell Polarity (PCP) pathway during mammalian development |
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developmental requirement for DACT1 during dendrite arborization, in hippocampal pyramidal neurons, is also present in cortical interneurons |
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plays a positive role in autophagy, and promotes the basal and starvation-induced autophagy |
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might play an important role in human placenta development via promoting Wnt signaling 9) |
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functions in embryonic development and tumorigenesis |
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DACT1 is critical to breast and prostate cancer bone metastasis |