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FLASH GENE
Symbol EAF1 contributors: mct/npt/pgu - updated : 15-02-2010
HGNC name ELL associated factor 1
HGNC id 20907
Location 3p24.3      Physical location : 15.469.063 - 15.484.119
Synonym name
  • ELL (eleven nineteen lysine-rich leukemia gene)-associated factor 1
  • eleven nineteen lysine-rich leukemia gene-associated factor 1
  • DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 15.06 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4503 - 268 - 2007 17395368
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Respiratorylung    
    Urinarykidney    
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an activation domain homologous with the AF4/FMR2 family
  • HOMOLOGY
    Homologene
    FAMILY
  • EAF family
  • ELL family transcription factors
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • strong positive regulator of ELL elongation activity
  • playing a role in regulation of RNA polymerase II transcription
  • shows structural similarities with EP400/Domino, a subunit of the NuA4-related TIP60 complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of Cajal bodies
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with RNA polymerase 2 transcriptional elongation factors
  • interacting with TFPT (TFPT is an important binding partner and a functional regulator of U19/EAF2, EAF1, and/or ELL)
  • MED26 can recruit EAF1 or EAF1-associated complexes to immobilized promoters via direct interaction of the MED26 NTD with EAF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS