basic FUNCTION
| catalyzing the posttranslational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins |
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regulator of hypoxia-inducible factor HIF alpha 1 subunit by prolylhydroxylation and targeting it to proteasome degradation |
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important mediator of neurotrophin withdrawal- mediated cell death |
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contributing in a non-redundant manner to the regulation of both HIF-1alpha and HIF-2alpha subunits |
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its regulation is an effective pathway for the control of the hypoxic response |
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enzyme mostly responsible for oxygen-induced degradation of HIF-A proteins |
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may function as a tumor suppressor gene in pancreatic cancer |
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serves as an oxygen sensor that rescues blood supply by regulating vessel formation and shape in case of oxygen shortage |
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regulates arteriogenesis and artery homeostasis by controlling a specific differentiation state in macrophages |
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oxygen/redox-sensitive enzyme that induces cellular adaptations to stress conditions |
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plays a pivotal role in the HIF pathway and has emerged as one of the most intriguing genes with respect to physiology at HA (high altitude) |
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EGLN3 with EGLN1, EGLN2 are cellular oxygen sensors that can mark HIF1A for von Hippel-Lindau protein-mediated proteasomal destruction |
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important role for EGLN1, EGLN3 as mediators of islet insulin secretion |