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FLASH GENE
Symbol ELF4 contributors: mct - updated : 05-02-2008
HGNC name E74-like factor 4 (ets domain transcription factor)
HGNC id 3319
Location Xq26      Physical location : 129.198.895 - 129.244.688
Synonym name ELF1 related
Synonym symbol(s) MEF, ELFR
DNA
TYPE anonymous DNA segment
STRUCTURE 45.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestine   moderately
 liver    
Endocrineparathyroid   highly
Lymphoid/Immunespleen   moderately
Nervousbrain    
Reproductivefemale systemovary   
 male systemprostate   
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal A transactivation domain
  • a central AT hook domain
  • a nuclear localization sequence
  • a C terminal ETS binding protein
  • HOMOLOGY
    interspecies ortholog to murine Elf4
    homolog to Drosophila Eip74EF
    homolog to C.elegans C24A1.2
    intraspecies homolog to ELF1 related
    Homologene
    FAMILY
  • elf-1/E74 family of ETS transcription factors
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • ETS-related transcription factor with strong transcriptional activating activity that affects hematopoietic stem cell behavior and is required for normal NK cell and NK T-cell development
  • activating transcription from the promoters of GM-CSF and IL3
  • regulating the proliferation of primitive hematopoietic progenitor cells at steady state, controlling their quiescence
  • plays an important role in the decision of stem/primitive progenitor cells to divide or remain quiescent by regulating their entry to the cell cycle
  • is involved in PTH suppression of osteoblasts through activating the MAP2K4/MAPK8 pathway and subsequently up-regulating MAB21L1 expression
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by several leukemia-associated fusion transcription factor proteins (PML-retinoic acid receptor alpha and AML1-ETO)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    targeted by the t(X;21)(q26;q22) in acute myelogenous leukemia
    tumoral fusion      
    fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS