Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | F2 | contributors: SGE/npt - updated : 28-11-2007 |
HGNC name | coagulation factor II (thrombin) |
HGNC id | 3535 |
|
Corresponding disease
Location
| 11p11.2
Physical location : 46.740.742 - 46.761.055 | Synonym name
|
| Synonym symbol(s)
| PT
| EC.number
| 3.4.21.5
| |
DNA |
TYPE | functioning gene |
STRUCTURE | 20.31 kb 14 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | restricted |
expressed in | (based on citations) | ||||||||||||||||||||
organ(s) |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
physiological period | fetal |
Text | fetal liver |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| |
| |
|
conjugated | GlycoP |
isoforms | Precursor | . proteolytically cleaved to form thrombin |
HOMOLOGY |
Homologene |
FAMILY |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | extracellular |
text | secreted in the plasma |
basic FUNCTION | |
| |
| |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | coagulation/hemostasis , development |
text | maintaining vascular integrity |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
| |
| |
| |
| |
|
cell & other |
REGULATION |
activated by | Kallicrein which can directly activate prothrombin (Stief 2008) |
ASSOCIATED DISORDERS |
corresponding disease(s) | F2 |
Susceptibility | to ischemic heart disease (IHD) |
Variant & Polymorphism other | G20210A heterozygosity alone and in combination with Factor V Leiden R506Q heterozygosity predicts 1.5 and 6.0 fold risk of IHD compared to non-carriers (Weischer 2009) |
Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |