basic FUNCTION
| cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin |
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inhibiting apoptosis through a calcineurin-dependent pathway |
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involved in the regulation of stress hormone-regulating hypothalamic -pituitary -adrenal axis through adaptive changes in glucocorticoid receptor |
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playing a role in immunoregulation and basic cellular processes involving protein folding and trafficking |
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suppressing the proliferation of colorectal adenocarcinoma, possibly due to the suppression of functions of the glucocorticoid receptors |
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plays an important role in glioma growth and chemoresistance through regulating signal transduction of the NF-kappaB pathway |
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promotes assembly of the HSP90 chaperone complex and regulates androgen receptor signalling in prostate cancer cells |
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favors the nuclear exclusion of corticosteroid receptors |
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major mitochondrial factor that undergoes nuclear-mitochondrial shuttling, an observation that may be related to antiapoptotic mechanisms triggered during the stress response |
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involved in regulation of the glucocorticoid response to stress-related disorders |
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promotes osteoclast differentiation by a mechanism distinct from NFKB1 activation, and FKBP5 might play a role in bone destruction and development of osteoporosis in RA as well as in glucocorticoid-induced osteoporosis |
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promoted activation of epithelial-to-mesenchymal transition (EMT) genes and improved melanoma cell migration and invasion |
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role for FKBP5 in the innate immune response to viral infection |
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role of the FKBP51-AKT1 kinase-synapsin pathway in stress responsiveness |
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role for FKBP5 in cytoskeletal rearrangement and cell migration and invasion |
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key regulator of endocrine stress responses in mammals and is a potential therapeutic target for stress-related disorders |
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as a stress-induced protein, FKBP5 uses re-setting of post-translational modifications (PTMs) to relay the effect of stress on various signaling pathways |
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FKBP5 independently and directly is regulating phosphorylation cascades and nuclear receptors |