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FLASH GENE
Symbol GTF3C2 contributors: KTN - updated : 04-12-2007
HGNC name general transcription factor IIIC, polypeptide 2, beta 110kDa
HGNC id 4665
Location 2p23.3      Physical location : 27.548.720 - 27.579.868
Synonym symbol(s) KIAA0011,TFIIIC-beta, TFIIIC110
DNA
TYPE functioning gene
STRUCTURE 31.00 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 splicing 3935 100 911 - -
19 splicing 3859 100 911 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveintestinelarge intestinecolon moderately
 intestinesmall intestine  lowly
 liver   lowly
Endocrinepancreas   lowly
Lymphoid/Immunespleen   lowly
 thymus   lowly
Nervousbrain   lowly
Reproductivefemale systemovary  moderately
 male systemtestis  lowly
 male systemprostate  lowly
Respiratorylung   moderately
Urinarykidney   specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, umbilial cord
PROTEIN
PHYSICAL PROPERTIES acid ,basic
STRUCTURE
motifs/domains
  • four WD 40 repeats (TRP-ASP domains)
  • stretches of acidic and basic regions
  • secondary structure
  • potential acidic and basic helices
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to dog GTF3C2 (93.7 pc)
    homolog to rattus Gtf3c2 (89.2 pc)
    homolog to murine Gtf3c2 (89 pc)
    Homologene
    FAMILY GTF3C family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs and adenoviral VA genes
  • initiating transcription complex assembly on tRNA
  • may play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    text
  • control of cell proliferation
  • PATHWAY
    metabolism
    signaling
    a component
  • beta subunit of the RNA polymerase III transcription factor TFIIIC
  • specific of TFIIIC2a
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS