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FLASH GENE
Symbol HIC2 contributors: npt/ - updated : 01-09-2008
HGNC name hypermethylated in cancer 2
HGNC id 18595
Location 22q11.21      Physical location : 21.771.692 - 21.805.748
Synonym name
  • HIC1 related gene on chromosome 22
  • zinc finger and BTB domain-containing protein 30
  • Synonym symbol(s) KIAA1020, HRG22, ZBTB30
    DNA
    TYPE functioning gene
    STRUCTURE 34.06 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text two isoforms produced by alternative splicing
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 6812 66 615 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum  
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • BTB/POZ domain
  • a conserved middle region
  • five C terminal zinc finger domains of the C2H2 type
  • HOMOLOGY
    interspecies homolog to chicken FBPB
    intraspecies homolog to HIC1
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • HIC subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • transcriptional repressor
  • putative antioncogene
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS