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FLASH GENE
Symbol HNRNPLL contributors: mct - updated : 12-01-2016
HGNC name heterogeneous nuclear ribonucleoprotein L-like
HGNC id 25127
Location 2p22.1      Physical location : -
Synonym name
  • stromal RNA-regulating factor
  • BLOCK24 protein
  • Synonym symbol(s) SRRF, HNRPLL
    DNA
    TYPE functioning gene
    STRUCTURE 41.06 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2797 - 537 - 2004 15256261
    13 - 3053 - 542 - 2004 15256261
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Reproductivefemale systemplacenta   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains three RRM (RNA recognition motif) domains
    conjugated RiboP
    HOMOLOGY
    interspecies homolog to murine Hnrpll (95.6pc)
    intraspecies paralog to HNRNPL
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • may be involved bone marrow stromal cells (MSC) differentiation pathway
  • both overlapping and divergent roles for HNRNPLL between conventional T cells and NKT cells
  • HNRNPLL and ELL2 are regulators of pre-mRNA processing in plasma cells
  • HNRNPLL and HNRNPL have overlapping, but distinct, expression patterns and functional consequences
  • induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA
  • is specifically induced in terminally differentiated lymphocytes, including effector T cells and plasma cells
  • RNA-binding protein HNRNPLL has a critical role in tuning transcriptomes of terminally differentiating B lymphocytes
  • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS
    text mRNA processing
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • is a critical inducible regulator of PTPRC alternative splicing
  • HNRNPLL expression is dependent on CD28 signaling, providing a mechanism by which CD28 can regulate splicing in T cells and insight into how HNRNPLL can influence signal-induced alternative splicing in T cells
  • HNRNPL and HNRNPLL thus antagonistically modulate PTB-mediated splicing suppression of exon P3A of CHRNA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS