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FLASH GENE
Symbol HSPE1 contributors: mct - updated : 03-04-2020
HGNC name heat shock 10kDa protein 1 (chaperonin 10)
HGNC id 5269
Location 2q33.1      Physical location : 198.364.720 - 198.368.186
Synonym name
  • 10 kDa chaperonin
  • chaperonin 10
  • early-pregnancy factor
  • epididymis secretory sperm binding protein
  • Synonym symbol(s) CPN10, HSP10, GROES, CH10, EPF
    DNA
    TYPE like-sequence
    SPECIAL FEATURE arranged in tandem, head to head
    text head to head with HSPD1
    STRUCTURE 3.07 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure bidirectional promoter with a SP1 transcription factor binding site
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 557 - 102 - 2017 29028811
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Reproductivefemale systemplacenta  highly Homo sapiens
     female systemovary  highly Homo sapiens
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage in trophoblast cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved DLFD motif within HSPE1 was critical for targeting NPAT and modulating histone transcription
  • mono polymer homomer , hexamer
    HOMOLOGY
    Homologene
    FAMILY GROES-CHAPERONIN family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • essential role for mitochondrial protein biogenesis together with HSPD1
  • is an endothelial-derived differentiation factor
  • may be involved in large bowel carcinogenesis
  • is important for S phase progression and cell proliferation )
  • HSPD1/HSPE1 may be implicated in the folding of membrane proteins
  • is reported to be involved in immunomodulation and tumor progression
  • elevated expression of HSPE1 protein inhibits apoptosis and associates with poor prognosis of astrocytoma
  • may likely have a maintenance role in Treg cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HSPE1 is a functional SIRT3 substrate and that, in response to prolonged fasting, SIRT3 levels modulate mitochondrial protein folding
  • HSPE1 is a novel interacting partner of NPAT
  • HSPD1 possesses a GTPase activity and mediates protein folding with HSPE1
  • cell & other
    REGULATION
    induced by by stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Mutations in GroES
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    HSP10-p.Leu73Phe mutation could be the cause or a strong contributing factor for infantile spasms
    constitutional     --low  
    in acute spinal cord injury
    tumoral     --over  
    of HSPE1 protein inhibits apoptosis and associates with poor prognosis of astrocytoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • HSPE1 could be a useful tumor tissue marker for the specific detection of bladder cancer
  • might be a novel independent biomarker for poor prognosis in invasive ductal breast carcinoma (IDBC)
  • Therapy target
    ANIMAL & CELL MODELS