basic FUNCTION
| coordinately regulating IFN-gamma production with antimicrobial humoral response |
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IL12RB1- and STAT3--dependent signals play likely a key role in the differentiation and/or expansion of human IL17-producing T cell populations |
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role of IL12RB1 and IL12RB2 for the expression of inducible nitric oxide synthase (iNOS) and production of NO in microglia that may participate in the pathogenesis of neuroinflammatory diseases |
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is essential for human resistance to multiple intracellular pathogens, including Mycobacterium tuberculosis |
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leukocytes primarily express IL12RB1 in an intracellular form located away from extracellular cytokine |
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in addition to promoting delayed type hypersensitivity (DTH), IL12RB1 also promotes autoimmunity |