basic FUNCTION
| involved in the differentiation of natural killer cells |
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inducing the differentiation of functional dendritic cells from peripheral blood monocytes |
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regulate the homeostasis of both innate and adaptive immune cells and lymphoid homeostasis |
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cytokine important for the development, maturation, and function of many cells of the immune system including NK, NKT, gammadeltaT, and CD8(+) T cells |
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its expression affects homeostasis and function of B cells through NK cell-derived IFNG |
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TNF significantly increased IL15-driven NK cell differentiation by increasing the expression of transcription factors that play crucial roles in NK cell maturation and inducing the NF-kappaB activity |
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intracellular IL15 is a potential key regulator of pathways controlling primary mast cell homeostasis |
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plays a crucial role in the development of follicular dendritic cells networks during germinal center reaction, offering a new target for immune modulation |
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supports the survival of effector CD8+ T cells after pathogen clearance, but its absence does not impair either primary or secondary effector CTL differentiation, nor does it impact the differentiation of long-term effector memory CD8+ T cells |
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activates multiple endothelial signaling events |
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key regulator of neurogenesis in the adult and is essential to understanding diseases with an inflammatory component |
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can induce the proliferation of Tregs in the presence of dendritics cells |
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critical role for IL15 in NKT cell survival, which is mediated by BCL2L1, and effector differentiation, which is consistent with a role of T-bet in regulating terminal maturation |
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IL15 signaling in NK cells is different from that of myeloid immune cells |
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has a negative regulatory role in fine-tuning of IL17A production and Th17-mediated inflammation |
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IL7- and IL15-mediated TCR sensitization enables T cell responses to self-antigens |