Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IL5RA contributors: mct - updated : 14-05-2008
HGNC name interleukin 5 receptor, alpha
HGNC id 6017
Location 3p26-p24      Physical location : 3.111.400 - 3.152.058
Synonym name CD125 antigen
Synonym symbol(s) CD125, CDw125, HSIL5R3, IL5R, MGC26560
DNA
TYPE functioning gene
STRUCTURE 40.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
text with an alternatively spliced secreted form
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2367 - 420 - Liu (2008)
- - 2024 - 333 - Liu (2008)
12 - 2299 - 420 - Liu (2008)
- - 1694 - 335 - Liu (2008)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Respiratoryrespiratory tracttrachea   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three FBN-like motifs
  • two cytokine receptor-like domains conserved WSXWS motif(s)
  • a cytoplasmic tail with a proline cluster
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • has a role for controlling eosinophils in the peripheral blood
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimerizing with CSF2RB
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to sporadic IgA nephropathy
  • to asthma development, especially in atopic populations
  • Variant & Polymorphism SNP increasing the risk of asthma development, especially in atopic populations
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS