Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol JMJD4 contributors: mct - updated : 25-11-2015
HGNC name jumonji domain containing 4
HGNC id 25724
Location 1q42.13      Physical location : 227.918.890 - 227.923.112
Synonym symbol(s) FLJ12517, MGC129896
DNA
TYPE functioning gene
STRUCTURE 4.31 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2564 - 447 - 2014 24486019
6 - 2612 - 463 - 2014 24486019
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Endocrineadrenal gland    
Lymphoid/Immunespleen   highly
 thymus    
Nervousbrain    
Reproductivemale systemprostate   
 male systemtestis   
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Jmjd4 (76.4pc)
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • regulator of translational termination—a fundamental cellular process required for decoding stop codons and maintaining protein sequence fidelity
  • JMJD4 catalysis promotes translational termination efficiency
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • catalyzes carbon 4 (C4) lysyl hydroxylation of ETF1
  • optimizes translational termination via lysyl hydroxylation of the stop codon recognition domain of an essential release factor termed ETF1
  • JMJD4 interacts with the ETF1/GSPT1 translational termination complex in an activity-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS