basic FUNCTION
| may be playing an important role in human brain function |
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involved in transcriptional regulation and chromatin remodeling |
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possessing H3K4 tri-demethylase activity and functioning as a transcriptional repressor |
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playing a direct role in chromatin dynamics, in REST (RE-1 silencing transcription factor )-mediated repression, and REST-mediated neuronal gene regulation |
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having a enzymatic activity required for its role in brain development and functioning as a transcriptional corepressor |
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being a novel Smad3 corepressor that may antagonize the tumor suppressing activity of the TGF-beta/Smad3 signaling pathway and thereby contributing to tumorigenesis |
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essential for notochord development 33 and 44 and dendrite arborization |
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KMD5C demethylase has been shown to remove methyl AAs from lysine 4 of histone H3 (H3K4), and constitutes an important component of the regulatory element-1-silencing transcription factor (REST) protein complex |
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involved in chromatin remodeling |
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histone demethylase specific to dimethylated and trimethylated histone 3 lysine 4 (H3K4ME2 and H3K4ME3, respectively), which are involved in chromatin remodeling |
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enzymatic activity of the KDM5 family required to be the linked JmjN-JmjC domain coupled with the immediate C-terminal helical zinc-binding domain, providing structural characterization of the linked JmjN-JmjC domain for the KDM5 family |