basic FUNCTION
| catalyzing the crucial step of the production of prostaglandin E2, which is a principal mediator of joint inflammation such as rheumatoid arthritis and osteoarthritis |
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confering maximal enhancer activity to the T-cell receptor-alpha enhancer |
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mediating the proliferation, survival and differentiation of granulocyte progenitor cells |
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regulating expression of cytokeratin genes involved in formation of hair follicles and the gene encoding the cell-adhesion molecule E-cadherin |
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instructive factor regulating neutrophilic granulopoiesis whose absence plays a critical role in the defective maturation program of myeloid progenitors in congenital neutropenia |
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plays important roles in organogenesis and colon cancer progression |
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having a role as a mediator of IL1B signaling in inflammatory process and constitutes further evidence for the role of WNT/CTNNB signaling in cartilage degeneration |
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directly regulating PTGS2 expression with CTNN1B in arthritic chondrocytes |
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having negative regulatory role in mature peripheral T cells and negatively controls interleukin-4 expression through a proximal promoter regulatory element |
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playing a role in the biology of acute leukemia, pointing to the necessity of balanced LEF1 expression for an ordered hematopoietic development |
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role in the Wnt signaling cross-talk that contributes to the initiation steps in hair follicle morphogenesis |
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high-mobility group of transcriptional factors that play essential roles in cell fate determination during early embryogenesis and ontogenesis |
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controls many developmentally regulated genes, including genes that activate expression of the T-cell antigen receptor alpha chain (TCR-alpha) in developing thymocytes |
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is a critical mediator of ERG-induced tumorigenesis |
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is an important factor for hematopoietic stem cells (HSCs) and progenitor function and that its stem cell regulatory role depends on its DNA binding ability |
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LEF1 promoted proliferation of renal cell carcinoma (RCC) cells depending on suppressing G2/M cell-cycle arrest |
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essential role for TCF7 and LEF1 in development of NKT cells |
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LEF1 reduces tumor progression and induces myodifferentiation in a subset of rhabdomyosarcoma |
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regulates circuit development that is fundamentally important for mediating anxiety in a wide variety of animal species |
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is required for neurogenesis |
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overexpressing LEF1 is sufficient to enhance neurogenesis, uncovering a novel mechanistic link between the BMP/WNT signalling pathways operating in adult hippocampal neural stem and progenitor cells |
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promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway |