SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
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| intracellular,nucleus
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text
| cytoplasmic in adenomas and carcinomas |
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may be secreted by a non-classical secretory pathway and associated with the cell surface |
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predominantly localized to the cell body peripherally along the Golgi zone |
basic FUNCTION
| multifunctional carbohydrate high affinity binding protein for advanced glycation end products (AGE) |
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playing a role in the process of metastasis in non small cell lung cancer |
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chemoattractant for monocyte and macrophage |
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potentially involved in myeloid cell differentiation |
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involved in the regulation of gene transcription when located in the nucleus |
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may function as an immune regulator to inhibit T-cell immune responses and promote tumor growth, thus providing a new mechanism for tumor immune tolerance |
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inhibitory regulator of T-cell activation and functions intracellularly by promoting TCR down-regulation, possibly through modulating PDCD6IP function at the immunological synapse |
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may exert anti or proapoptotic activity depending on the cell type and the nature of stimulus |
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promotes cell migration during re-epithelialization of corneal wounds |
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may mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration |
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may exhibit anti- or pro-apoptotic activity depending on its localization and post-translational modifications |
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modulates VEGFA- and FGF2-mediated angiogenesis by binding via its carbohydrate recognition domain |
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involved in RNA processing and cell cycle regulation through activation of transcription factors when translocated to the nucleus |
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LGALS3-dependent regulation of MUC1/EGFR functions may represent an interesting mechanism modulating the EGFR-stimulated cell growth of pancreatic cancer cells |
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having a critical role in embryo implantation |
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promotes oligodendrocyte differentiation, thus contributing to myelin integrity and function with critical implications in the recovery of inflammatory demyelinating disorders |
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regulates proliferation and migration in cancer and is expressed by activated macrophages after brain injury |
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important in subventricular zone neuroblast migration, possibly through an EGFR-based mechanism, and playing a role in the uninjured brain |
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like its role with the EGF and TGFB receptors, contributes to the plasma membrane retention and proangiogenic function of KDR |
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crucial role of cytosolic LGALS3 in controlling intracellular trafficking and cell surface expression of EGFR after EGF stimulation |
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role in stabilizing a desmosomal cadherin and intercellular adhesion in intestinal epithelial cells |