Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LHB contributors: mct - updated : 12-10-2022
HGNC name luteinizing hormone beta polypeptide
HGNC id 6584
Corresponding disease
HH23 hypogonadotropic hypogonadism 23 with or without anosmia
Location 19q13.33      Physical location : 49.519.237 - 49.520.347
Genatlas name see CGB@
Synonym name lutropin, beta chain
Synonym symbol(s) CGB4, LSH-B
DNA
TYPE functioning gene
STRUCTURE 3.52 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 525 - 141 - 2020 32475064
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
 neuroendocrinepituitary   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY glycoprotein hormone beta chain family
CATEGORY signaling hormone
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,lumen
intracellular,cytoplasm,organelle,Golgi
basic FUNCTION
  • promoting spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • upstream region of LHB is one of the target sites for glucoprivation inducing AMPK activation, and AMPK plays a role in repressing LHB expression through the distal -2527 to -2198b region
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HH23
    Susceptibility to variation on the outcomes of in vitro fertilisation (IVF) and embryo transfer
    Variant & Polymorphism other
  • with a common genetic variant-leading in the heterozygous or homozygous type to slight but significant alterations in ovarian steroidogenesis
  • Trp8Arg polymorphism of the LHB gene has decreased bioactivity and a role on the IVF outcome
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS