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FLASH GENE
Symbol LRMP contributors: mct/npt - updated : 16-05-2008
HGNC name lymphoid-restricted membrane protein
HGNC id 6690
Location 12p12.1      Physical location : 25.205.240 - 25.261.268
Synonym name protein Jaw1
Synonym symbol(s) EVI79, JAW1
DNA
TYPE functioning gene
STRUCTURE 56.00 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2826 - 499 - Manenti (2006)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell
Lymphoid/ImmuneB cell
Lymphoid/ImmuneT cell
cell lineage
  • B cell lineage
  • T cell lineage
  • cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal cytosolic domain
  • a coiled-coil domain
  • a transmembrane region
  • a C terminal membrane anchor with a conserved lumenal tail region, 71 AAs, which contain a hydrophobic membrane spanning region, are sufficient to target a heterologous protein to the ER
  • isoforms Precursor cleavage of a C terminal peptide
    HOMOLOGY
    interspecies ortholog to murine Lrmp
    homolog to rattus Rn.54706
    Homologene
    FAMILY
    CATEGORY unknown/unspecified , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text
  • localized to the cytoplasmic face of the endoplasmic reticulum
  • single-pass type IV membrane protein
  • basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text hemocytes development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in diffuse large B-cell lymphomas of 'germinal centre' subtype
    Susceptibility to lung cancer
    Variant & Polymorphism other V141L polymorphism is associated with survival of lung cancer patients
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS