basic FUNCTION
| involved in the regulation of cell survival, proliferation, and differentiation |
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transactivating the expression of the CLU gene |
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acting as a negative regulator of vascular smooth muscle cell matrix gene transcription |
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elevates endogenous ADORA2B mRNA and receptor activity, and this activity decreases cell proliferation |
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transcription factor belonging to the MYB family that is frequently overexpressed or amplified in different types of human malignancies |
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nuclear transcription factor involved in cell-cycle progression |
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enhances STRAP-mediated inhibition of TGFB signaling pathways, such as apoptosis and growth inhibition, by modulating complex formation between the TGFB receptor and SMAD3 or SMAD7 |
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acts as a positive regulator of STRAP |
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plays potentially a subtle but key role in linking specific aspects of cell-cycle progression with generation of signals for differentiation and may therefore be fundamental in commitment of intestinal epithelial cells to differentiation pathways during their maturation |
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LIN9 and MYBL2 were both required for transcription of G(2)/M genes such as CCCNB1 and Survivin |
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novel role for MYBL2 in S-phase that appears to be independent of its sequence-specific DNA-binding activity and its ability to stimulate the expression of bona fide MYBL2 target genes |
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