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FLASH GENE
Symbol MYEF2 contributors: mct - updated : 26-10-2017
HGNC name myelin expression factor 2
HGNC id 17940
Location 15q21.1      Physical location : 48.431.630 - 48.470.558
Synonym symbol(s) MEF-2, FLJ11213, KIAA1341, MST156, MSTP156, HsT18564, MGC87325, myEF-2
DNA
TYPE like-sequence
STRUCTURE 43.89 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 5403 - 600 - 2003 2039974
16 - 5335 - 576 - 2003 2039974
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three RRM domains
  • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Myef2 (94.3pc)
    homolog to rattus Myef2 (91.0pc)
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • transcriptional repressor of the myelin basic protein gene
  • MYEF2 is bound in undifferentiated cells and is lost upon differentiation, whereas KDM1A is bound in differentiated cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the proximal MB1 element 5'TTGTCC3' of the MBP promoter
    RNA binding
    small molecule
    protein
  • inhibitor of MBP
  • RUNX1 interacts with two novel protein partners, KDM1A and MYEF2, in erythroid cells
  • cell & other
    REGULATION
    inhibited by PURA
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS