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FLASH GENE
Symbol N4BP2 contributors: - updated : 15-04-2005
Location 4p14      Physical location : 40.058.523 - 40.157.017
Genatlas name Nedd4 binding protein 2
Synonym name BCL-3 binding protein
Synonym symbol(s) B3BP, FLJ10680, KIAA1413
DNA
TYPE functioning gene
STRUCTURE 59.00 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a polynucleotide kinase domain (PNK) near the N-terminal region
  • N-terminal region containing the ATP-binding site important for the interaction with BCL-3 and p300/CBP
  • a small MutS Related (Smr) domain near the C-terminal region, involved in the DNA repair or recombination reaction
  • conjugated Other
    HOMOLOGY
    interspecies ortholog to murine B3bp
    Homologene
    FAMILY
    CATEGORY enzyme , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having 5'-polynucleotide kinase and nicking endonuclease activity
  • may play a role in transcription-coupled DNA repair or genetic recombination
  • playing a critical role in the development of a normal immune response and the formation of germinal centers in secondary lymphoid organs
  • CELLULAR PROCESS nucleotide, recombination
    nucleotide, repair, mismatch repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ubiquitinated
  • INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • NEDD4
  • interacting specifically with the bcl-3 gene product (BCL3)
  • CREBBP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS