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FLASH GENE
Symbol NAA25 contributors: mct - updated : 16-03-2015
HGNC name N(alpha)-acetyltransferase 25, NatB auxiliary subunit
HGNC id 25783
Location 12q24.13      Physical location : 112.464.493 - 112.546.635
Synonym name
  • mitochondrial distribution and morphology 20
  • Synonym symbol(s) NATB, NAP1, MDM20, C12orf30
    DNA
    TYPE
    STRUCTURE 82.33 kb     24 Exon(s)
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 5825 - 972 - 2012 22101279
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Mus musculusFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY Nat family protein
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may function either with an unidentified Nat protein partner(s) or possibly in a Nat-independent manner
  • NAA25/NAA20 complex-mediated acetylation may play a role in the proliferation and differentiation of neural progenitors
  • auxiliary subunit of the translation-coupled protein N-acetylation complex, contributing to protein clearance and/or aggregate formation by affecting the phosphorylation level of AKT1 independently from the function of NAA20
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NAA20 is only a known member of Nat family protein that interacts with NAA25
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS