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FLASH GENE
Symbol NUTM1 contributors: mct - updated : 11-07-2012
HGNC name NUT midline carcinoma family member 1
HGNC id 29919
Location 15q14      Physical location : -
Genatlas name nuclear protein in testis
Synonym name
  • chromosome 15 open reading frame 55
  • Synonym symbol(s) DKFZp434O192, MGC138683, MGC138684, C15orf55
    DNA
    TYPE functioning gene
    STRUCTURE 11.87 kb     7 Exon(s)
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3795 120 1132 - 2005 15994877
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
  • FAM22 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • contains nuclear localization and export sequences that promote nuclear-cytoplasmic shuttling via a leptomycin-sensitive pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BRD-NUT fusion proteins contribute to carcinogenesis by associating with chromatin and interfering with epithelial differentiation
  • BRD4-NUT oncogene perturbs BRD4 functions to block cellular differentiation and to contribute to the oncogenic progression in the highly aggressive NUT midline carcinoma
  • can interact with additional HAT enzymes such as TIP60 and GCN5 to induce the histone hyperacetylation on chromatin
  • NUT can interact with additional HAT enzymes such as KAT5 and KAT2A to induce the histone hyperacetylation on chromatin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with BRD4 in t(15;19)(q13.2;p13.1) inhibiting S phase in rare lung carcinoma, and thymic carcinomas, highly lethal carcinoma (
    tumoral fusion      
    MXD4-NUTM1 fusion transcript identified in primary ovarian undifferentiated small round cell sarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS