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FLASH GENE
Symbol OTOP1 contributors: mct - updated : 19-01-2016
HGNC name otopetrin 1
HGNC id 19656
Location 4p16.3      Physical location : 4.190.529 - 4.228.621
DNA
TYPE functioning gene
STRUCTURE 38.09 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1869 - 612 - 2003 12651873
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Cardiovascularheart    
Digestivestomach    
Endocrineadrenal gland    
Reproductivefemale systembreastmammary gland  
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningepidermis  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text developing otocyst of the inner ear
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • multitransmembrane domains
  • dimeric and each subunit forming 12 transmembrane helices divided into structurally similar amino (N) and carboxy (C) domains
  • mono polymer dimer
    HOMOLOGY
    interspecies ortholog to murine Otop1
    intraspecies paralog to OTOP2, OTOP3
    Homologene
    FAMILY
  • Otopetrin Domain Protein (ODP) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text overlying otolithic membrane
    basic FUNCTION
  • may be integral to the membrane vesicles that are released into the gelatinous membrane, which may foster lattice crystal formation
  • involved in vestibular function
  • implicated in depletion of endoplasmic reticulum Ca(2+) stores, specific inhibition of P2RY2, and regulation of the influx of extracellular Ca(2+) in response to ATP, ADP, and UDP
  • is necessary for the formation of otoconia and otoliths, calcium carbonate biominerals within the inner ear of mammals and teleost fish that are required for the detection of linear acceleration and gravity
  • multitransmembrane domain protein, which is essential for mineralization of otoconia, the calcium carbonate biominerals required for vestibular function, and the normal sensation of gravity
  • acts potentially as a sensor of the extracellular calcium concentration near supporting cells and responds to ATP in the endolymph to increase intracellular calcium levels during otoconia mineralization
  • essential for the development of otoconia, the extracellular calcium carbonate containing crystals important for vestibular mechanosensory transduction of linear motion and gravity
  • modulate purinergic control of intracellular calcium in vestibular supporting cells, which could be one of the mechanisms by which OTOP1 participates in the mineralization of otoconia
  • protein required for development of gravity-sensing otoconia in the vestibular system, as forming a proton-selective ion channel
  • OTOP1 functions as a sour taste receptor
  • members of the OTOP channel family are proton-gated (acid-sensitive) proton channels and that the gating apparatus is distributed across multiple extracellular regions within both the N and C domains of the channels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • P2RY2 interacting with OTOP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • murine Otop1 is enriched in acid-detecting taste receptor cells and is required for their zinc-sensitive proton conductance