basic FUNCTION
| regulating EIF4G-dependent translation through direct interaction with EIF4G and RPS13 in senescent fibroblasts |
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inhibiting the translation initiation factor EIF4A |
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inhibiting tumor promoter-induced neoplastic transformation |
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down-regulating the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription |
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inhibit invasion by activating activator protein-1 (AP-1) |
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inhibits invasion/intravasation and regulates urokinase receptor PLAUR gene expression via Sp-transcription factors |
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involved in TGFB1-induced apoptosis via the SMAD pathway |
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involved in the regulation of transcription and translation |
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directly involved in translational suppression of a natural mRNA, providing the first evidence for a key role of the RNA-binding domain in targeting PDCD4 to a specific mRNA |
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critical suppressor of apoptosis by inhibiting the translation of procaspase-3 mRNA |
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by affecting the translation and activity of TP53, is likely to exert pleiotropic effects on these biological processes and thereby influence the cellular homeostasis |
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may play a critical function in arresting cell cycle progression at key checkpoint, thus inhibiting cell proliferation, as well as suppressing tumour metastasis |