basic FUNCTION
| an essential nuclear peptidylprolyl cis-trans isomerase nvolved in regulation of mitosis |
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stimulating the DNA-binding activity and transactivation function of TP53 and p73 and by modulating cell proliferation through stabilization of cyclin D1, alpha catenin 18, NF-KB |
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implicated in the amplification of oncogenic signals by its cooperation with the Neu/Ras pathway in mammary tumorigenesis |
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has a role in the activation of human Notch1, through modulation of its cleavage by alpha-secretase in tumorigenesis |
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crucial activity of Pin1 in the control of DNA damage checkpoint pathways, by regulating the functions of p53 |
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restoring the function of Alzheimer-associated phosphorylated tau protein (MAPT) |
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involved in the regulation of mitosis by modulating the NIMA pathway |
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may mediate the function of PRKX in kidney development |
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phosphorylation-specific isomerase regulating centrosome duplication (its deregulation can induce centrosome amplification, chromosome instability, and oncogenesis) |
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regulates diverse cellular processes, including growth-signal responses, cell-cycle progression, cellular stress responses, neuronal function and immune responses |
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essential role in maintaining cell proliferation and regulating cyclin D1 function |
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essential for activation of the apoptotic response by endogenous p73 |
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enhances STAT3-mediated epithelial-mesenchymal transition in breast cancer cells induced by oncostatin M |
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specifically recognizes the pSer/Thr-Pro motifs on its target proteins, and interacts with STAT3 upon cytokine/growth factor stimulation |
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may be neuroprotective against neurodegeneration in AD (Alzheimer disease) |
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involved in neurodegeneration |
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promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity |
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essential regulator of TERF1 stability, telomere maintenance and ageing |
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catalyzes the cis-trans conformational changes of p27(Kip1) and further mediates its stability through the polyubiquitination mechanism |
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acts as a switch to control the degree of substrate ubiquitylation |
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critical cell cycle regulator that modulates the function of many phosphorylated proteins during G2/M transition |
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could stabilize or provide additional protein-protein interaction surfaces in a catalytic-dependent manner, thereby favoring the interaction of ADRBK1 with other E3 ligases |
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amplifies EGF signaling in breast cancer cells through its interaction with MAP2K1 and then enhances ERBB2 expression |
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regulates CRE transcriptional activity, by associating with CRTC1 or CRTC2 |
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regulates the functions and subcellular localizations of CRTC family proteins, thereby altering CRE transcriptional activity |
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novel role for PIN1 as a regulator of muscle terminal differentiation and may be PIN1-mediated repression of MEF2C function could contribute to this function |
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negatively modulates skeletal muscle differentiation, a function that can be explained partly by the inhibition of stability and activity of MEF2C |
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might regulate cellular processes distinct from the cell cycle itself, such as terminal differentiation through a modulation of differentiation-specific gene expression |
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indispensable for the self-renewal and maintenance of pluripotent stem cells via the regulation of phosphorylated POU5F1 and other substrates |
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control cell-cycle progression and is required for G2/M transition |
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a putative regulator of the induction and maintenance of pluripotency via the control of phosphorylation signaling |
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could act as a molecular switch that can reversibly control the proliferation and survival of induced pluripotent stem cells, thereby reducing the risk of cell transformation and tumor formation |
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has many important spindle substrates, and this might represent a general mechanism for localization of mitotic signalling proteins |
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apparently restrains the ability of CAST to inhibit calpain, maintaining calpain activity in endothelial cell |
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recognizes specific conformations of its substrate by conformational selection |
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has an important role in cell proliferation by isomerizing NR4A1 |
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nuclear protein peptidyl-prolyl isomerase PIN1-mediated prolyl isomerization is an essential and novel regulatory mechanism for protein phosphorylation |
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regulates large numbers of phospho proteins having diverse cellular functions, including in the cell cycle, cell transformation, and apoptosis |
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PIN1 is a new regulator of RUNX3 inactivation in breast cancer |
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PIN1-mediated inhibition of FBXW7 contributes to oncogenesis |
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modulates the production of many pro- and antifibrogenic cytokines and ECM |
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coordinates the production and accumulation of ECM by regulating intracellular, SMAD-dependent signaling |
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PIN1 is a new and essential factor regulating CPEB1 degradation |
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critical role for SENP1-mediated deSUMOylation in promoting PIN1 function during tumorigenesis |
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acts as a negative regulator of the G2/M transition by interacting with the AURKA-BORA complex |
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both SEPT9 and PIN1 are critical for mediating the final separation of daughter cells |
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PIN1, similar to SEPT9, is required for abscission in human cells, and its depletion causes phenotypes similar to knockdown of SEPT9, controlling a previously uncharacterized step in abscission |
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PIN1-mediated isomerization, in response to phosphorylation, may serve as an evolutionarily conserved mechanism of regulating septin function in a variety of cellular contexts |
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promotes histone H1 dephosphorylation and stabilizes its binding to chromatin |
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conserved function of HIPK2 and PIN1 in the DNA damage-induced apoptosis response |
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PIN1 mediates HIPK2 isomerization and, thereby, alters HIPK2 conformation |
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novel function of PIN1 in neurodevelopment |