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FLASH GENE
Symbol PLAU contributors: mct - updated : 12-06-2017
HGNC name plasminogen activator, urokinase
HGNC id 9052
Location 10q22.2      Physical location : 75.670.861 - 75.677.256
Synonym name
  • urokinase-type plasminogen activator
  • Synonym symbol(s) UPA, URK, ATF, QPD, UPA, URK, u-PA, BDPLT5
    EC.number 3.4.21.73
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text NFKBL embedded in PLAU promoter region
    STRUCTURE 6.40 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - PLAU - HOX11 - qter
    Authors Stein (93)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2680 - 414 - 2014 24549574
    11 - 2395 - 431 - 2014 24549574
    10 - 2315 - 345 - 2014 24549574
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrinepancreas   highly
    Nervousbrain    
    Respiratorylung   highly
     respiratory tractlarynx   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion urine
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cysteine-rich kringle domain
  • one EGF-like domain
  • HOMOLOGY
    Homologene
    FAMILY peptidase family S1
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • plasminogen activator, urokinase serine protease, involved in plasminogen activation to plasmin
  • playing a role in the regulation of monocyte/macrophage functions, such as that occurring in inflammatory reactions
  • critical role for PLAU in Treg suppressor function
  • IL6, JUN, and PLAU may be involved in development of neuropathic pain
  • is involved in cell migration, proliferation and tissue remodeling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SP100 interacts with the ETS1 transcription factor, reduces ETS1-DNA binding and inhibits ETS1 transcriptional activity on the MMP1 and PLAU promoters
  • SERPINB2 is a potent inhibitor of urokinase-type plasminogen activator (PLAU) and also acts as a multifunctional protein
  • BRMS1 recruits HDAC1 to the NF-kappaB binding site of the PLAU promoter, modulates histone acetylation of RELA on the PLAU promoter, leading to reduced NF-kappaB binding activity on its consensus sequence, and reduced transactivation of PLAU expression
  • mediates Treg suppressor function via STAT5 and ERK signaling pathways
  • HMGA1 has a direct role in regulating the transcription of PLAU and SERPINE1 which may constitute an important mechanism by which HMGA1 promotes cancer progression
  • MMD-dependent secretion of a protease, PLAU, prevents anoikis and initiates autocrine activation of a PLAU receptor/signal transducer
  • activation of STING inhibits cancer cell migration and invasion by suppressing PLAU
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    could suppress tumor growth
    Susceptibility
  • to Alzheimer disease
  • to myocardial infarction (MI)
  • Variant & Polymorphism other
  • polymorphism increasing the risk of Alzheimer disease
  • rs4065 might be a previously unknown genetic risk factor for MI
  • Candidate gene
    Marker
  • can be a diagnostic and prognostic biomarker in in head and neck squamous cell carcinoma (HNSCC)
  • Therapy target
    ANIMAL & CELL MODELS