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FLASH GENE
Symbol PLEKHG1 contributors: mct - updated : 06-09-2017
HGNC name pleckstrin homology domain containing, family G (with RhoGef domain) member 1
HGNC id 20884
Location 6q25.1      Physical location : 150.920.998 - 151.164.799
Synonym name PH domain
Synonym symbol(s) KIAA1209, ARHGEF41
DNA
TYPE functioning gene
STRUCTURE 243.80 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 7237 - 1385 - 2011 20641033
- - 7264 - 1444 - 2011 20641033
- - 7178 - 1425 - 2011 20641033
- - 7305 - 1385 - 2011 20641033
- - 7293 - 1385 - 2011 20641033
- - 7254 - 1372 - 2011 20641033
- - 7176 - 1346 - 2011 20641033
- - 4603 - 545 - 2011 20641033
- - 4557 - 545 - 2011 20641033
- - 4613 - 545 - 2011 20641033
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one PH domain
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • with ARHGEF10, ARHGEF2, ARHGEF12, PLEKHG1 and ARHGEF28, are involved in cyclic-stretch-induced perpendicular reorientation of endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS