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FLASH GENE
Symbol POR contributors: mct - updated : 06-06-2012
HGNC name P450 (cytochrome) oxidoreductase
HGNC id 9208
Corresponding disease
ANBXL2 Antley-Bixler syndrome 2
DSTG disordered steroidogenesis, isolated
PORD POR deficiency
Location 7q11.23      Physical location : 75.544.419 - 75.616.172
Synonym name NADPH--cytochrome P450 reductase
Synonym symbol(s) NCPR, CYPOR, CPR, P450R, FLJ26468, DKFZp686G04235
EC.number 1.6.2.4
DNA
TYPE functioning gene
STRUCTURE 71.75 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure
  • no TATA, no CAAT boxes, house keeping gene
  • Sp1
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2509 - 680 - 2005 16125667
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Endocrineadrenal gland   highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • a flavodoxin-like domain
  • a FAD-binding domain
  • conjugated FlavoP
    HOMOLOGY
    interspecies homolog to murine Por
    Homologene
    FAMILY
  • P450 heme-binding monooxygenase superfamily
  • FAD-FMN family of proteins
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • required for electron transfer from NADP to cytochrome p450 in microsomes
  • can also provide electron transfer to heme oxygenase and cytochrome B5
  • electron donor for all microsomal P450 enzymes including CYP26A1 involved in inactivation of all-trans retinoic acid
  • flavoprotein that acts as the obligatory electron donor to all microsomal P450 enzymes, including those involved in hepatic drug metabolism as well as three steroidogenic P450 enzymes
  • microsomal electron-transferring enzyme, which provides the reducing equivalents to various redox partners, such as cytochromes P450 (CYPs), heme oxygenase (HO), cytochrome b(5) and squalene monooxygenase
  • involved in regulation of gap junction function and GJA1 may play an important role in POR-mediated bone defects seen in patients
  • plays a role in transcriptional regulation of GJA1 in osteoblasts and, as a consequence could be an important player in POR-mediated bone development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • FAD electron acceptor rom NADPH
  • FMN electron donor to acdeptors such as the cytochrome as well as enzymes involved in sterol,fatty acid metabolism and degradation of heme
  • protein
  • PGRMC1 binds to POR, which may influence CYP2B6 activity
  • can regulate GJA1 expression at the transcription level and decreases in POR reduce gap junctional intercellular communication, as well as hemichannel activity
  • cell & other
    REGULATION
    induced by pituitary-thyroid axis,thyroid hormone T3
    ASSOCIATED DISORDERS
    corresponding disease(s) ANBXL2 , DSTG , PORD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS