basic FUNCTION
| is a novel factor involved in the response to DNA replication stress |
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is a highly error-prone polymerase regulated by single-stranded DNA binding protein |
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/ PRIMPOL implicated in promoting restart of DNA synthesis downstream of, but closely coupled to, G4 replication impediments |
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ability of PRIMPOL to function as a DNA primase stems from a simple but remarkable feature-almost complete lack of contacts to the DNA primer strand |
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is capable of acting as a DNA polymerase, with the ability to extend primers and also bypass a variety of oxidative and photolesions |
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is a human deoxyribonucleic acid (DNA) polymerase that also possesses primase activity and is involved in DNA damage tolerance, the prevention of genome instability and mitochondrial DNA maintenance |
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can reinitiate stalled mtDNA replication and can prime mtDNA replication from nonconventional origins |
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is a monomeric enzyme whose DNA primase activity is required to rescue stalled replication forks during nuclear and mitochondrial DNA replication |
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is an enzyme that maintains efficient DNA duplication by repriming replication restart downstream of replicase stalling lesions and structures |
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importance of PRIMPOL for maintaining efficient DNA replication in unperturbed cells and its complementary roles, with POLH, in damage tolerance in human cells |
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is a primase/polymerase specialized in re-starting stalled forks by repriming beyond lesions such as pyrimidine dimers, and replication-perturbing structures including G-quadruplexes and R-loops |