Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | PRKG1 | contributors: mct - updated : 30-01-2024 |
HGNC name | protein kinase, cGMP-dependent, type I |
HGNC id | 9414 |
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Corresponding disease |
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Location | 10q21.1 Physical location : 52.750.944 - 54.055.274 | ||
Synonym name | |||
Synonym symbol(s) | PRKGR1, PKG1, PGK, CGKI, PRKG1B, PKG, DKFZp686K042, FLJ36117, MGC71944, cGK-I, AAT8 cGK1, cGKI-BETA, cGKI-alpha | ||
EC.number | 2.7.1.37/ 2.7.11.12 |
DNA |
TYPE | functioning gene |
STRUCTURE | 1307.46 kb 18 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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text | with two alternatively spliced isoforms,1 alpha,1 beta |
EXPRESSION |
Type |
expressed in | (based on citations) | ||||||||||||||||||||
organ(s) |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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8764;50 AAs of the kinase are required for homodimerization and association with isoform-specific PKG-anchoring proteins (GKAPs), which target the kinase to specific substrates |
mono polymer | homomer , dimer |
HOMOLOGY |
interspecies | ortholog to Drosophila foraging |
Homologene |
FAMILY | PRK family |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,organelle,Golgi | |
intracellular,cytoplasm,cytosolic | |
intracellular,nucleus,nucleoplasm |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
Other | its expression is subjected to post-transcriptional regulation in vascular smooth muscle cells through the 3 prime UTR of its mRNA |
TP53 is a transcription factor that regulates the expression of PRKG1 during neuronal maturation and cGMP-dependent inhibition of growth cone collapse |
ASSOCIATED DISORDERS |
corresponding disease(s) | TAAD6 |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |
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