| knockout mice carrying a homozygous null mutation in perhipherin/rds fail to develop photoreceptor outer segments | |
an insertion of a 9.2-kb repetitive genomic element into rds exon 2 is responsible for the murine Mouse "retinal degeneration, slow (rds)" defect |
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transgenic/knockout mice that duplicate the amino acid substitutions and predicted levels of rds and rom1 in patients with RDS-mediated digenic and dominant RP display a faster photoreceptor degeneration |
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transgenic/knockout mice that duplicate the amino acid substitutions and predicted levels of rds and rom1 in patients with RDS-mediated digenic and dominant RP exhibit photoreceptor degeneration by outer segment disorganization |
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Mice homozygous for the retinal degeneration slow (rds) mutation exhibit abnormal development of photoreceptor cells, followed by their slow degeneration |
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single base deletion at codon 307 of the rds-peripherin gene in mice have a more rapid retinopathy than that in the naturally occurring null mutant rds(-/-) mouse |
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R172W/rds(-/-) mice display cone-rod dystrophy |
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rhodopsin-knockout mice failed to create normal rod outer segments and instead, elaborated membranous protrusions at the distal cilium tip |
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subretinal injection of recombinant adeno-associated virus (AAV) encoding a Prph2 transgene in rds mice results in stable generation of outer segment structures and formation of new stacks of discs containing both perpherin-2 and rhodopsin |