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FLASH GENE
Symbol RAPGEF6 contributors: mct - updated : 06-04-2011
HGNC name Rap guanine nucleotide exchange factor (GEF) 6
HGNC id 20655
Location 5q31.1      Physical location : 130.759.615 - 130.970.929
Synonym name
  • PDZ domain containing guanine nucleotide exchange factor (GEF) 2
  • rap guanine nucleotide exchange factor
  • PDZ domain-containing guanine nucleotide exchange factor I
  • Synonym symbol(s) PDZGEF2, RA-GEF-2, DKFZp667N084, DKFZp686I15116, KIA001LB, PDZ-GEF2, RAGEF2
    DNA
    TYPE functioning gene
    STRUCTURE 211.32 kb     28 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 8371 - 1601 - 2010 20800573
    28 - 8080 - 1504 - 2010 20800573
    29 - 8395 - 1609 - 2010 20800573
    29 - 8095 - 1509 - 2010 20800573
    - - 4524 - 1391 - 2010 20800573
    - - 3127 - 827 - 2010 20800573
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PDZ domain, a cyclic nucleotide-binding domain
  • a RasGEF domain
  • an SH3 domain
  • PPDY motif at the C-terminus binding to the WW domain of BAG3
  • HOMOLOGY
    Homologene
    FAMILY multiple-member family of guanine nucleotide exchange factors (GEFs) for RAP1
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • promoting the exchange of RAS-bound GDP by GTP
  • specifically responsible for the activation of RAP1 that mediates tumor necrosis factor-alpha (TNF-alpha)-triggered integrin activation
  • crucial role of the cross-talk between two Ras-family GTPases MRAS and RAP1, mediated by RAPGEF6, in adhesion signaling
  • activates RAP1A and RAP1B to perform different functions and plays a critical role in the maturation of adherens junctions
  • critical partner for BAG3 in regulating cell adhesion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerization facilitates formation of a complex with MLLT4 and PDZGEF2 that activates RAP1A, which regulates beta1 integrin levels and cell migration
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically and functionally associated with the PDZ domain-containing MLLT4 and F11R, but not zonula occludens (ZO)-1, in epithelial cells
  • BAG3-interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS