basic FUNCTION
| generating all-trans retinal from all-trans retinol |
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playing an important role in the photic visual cycle |
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first oxidative step of Vitamin A metabolism, which is catalyzed in large part by the retinol dehydrogenase RDH10, is critical for the spatiotemporal synthesis of RA |
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essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development |
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essential for generating retinoic acid at early embryonic stages |
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primary RDH responsible for the first step of embryonic Vitamin A oxidation |
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major contributor to retinal biosynthesis during mid-gestation |
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plays a critical role in mediating the rate limiting retinol dehydrogenase step of Vitamin A metabolism and functions as a nodal point in feedback regulation of RA synthesis |
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RDH10-mediated oxidation of retinol plays as important a role in the control and regulation of RA production during embryogenesis as does the subsequent RALDH-mediated reaction |
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RDH10 and ALDH1A2 are critical for RA biosynthesis in the embryo |