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FLASH GENE
Symbol RPAP3 contributors: mct - updated : 19-08-2011
HGNC name RNA polymerase II associated protein 3
HGNC id 26151
Location 12q13.11      Physical location : 48.055.715 - 48.099.844
Synonym symbol(s) FLJ21908, spag
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
STRUCTURE 44.13 kb     17 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 3687 - 665 - 2013 23159623
  • interacted with PIH1D1
  • 16 - 3528 - 506 - 2013 23159623
    16 - 3585 - 631 - 2013 23159623
  • may reduce the interaction of endogenous RPAP3 isoform 1 with PIH1D1 with a dominant negative effect on the R2TP complex
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   highly
    Lymphoid/Immunespleen   highly
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
     male systemtestis  predominantly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two helix-turn-helix tetratricopeptide repeats (TPR) characteristic of chaperone cofactors
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • with Monad (WDR92), may function as a novel modulator of apoptosis pathway
  • promotes TNFA-induced apoptosis through death receptor-mediated caspase-3 activation pathway
  • modulates UV-induced DNA damage by regulating H2AX phosphorylation
  • with binding to WDR92 and PIH1D1, regulates apoptosis, indicating the possibility that the function of the R2TP/prefoldin-like complex (containing WDR92) may be related to the regulation of apoptosis in mammalian cells
  • RPAP3 and WDR92 promote apoptosis
  • may be a novel modulator of NF-kappaB pathway in apoptosis induced by anti-cancer chemotherapeutic agents
  • might be a powerful tool to enhance cytotoxicity of anti-cancer agents against breast cancer
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component chaperon complex R2TP composed of RUVBL1, RUVBL2, RPAP3, and PIH1D1 and prefoldin-like complex (including WDR92) in mammalian cells
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with WDR92
  • PIH1D1 interacts with both RPAP3 and WDR92
  • binding with IKBKG and inhibiting the ubiquitination of IKBKG
  • RPAP3, RUVBL1, RUVBL2,and PIH1D1 were identified as WDR92 binding proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS