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Symbol SFXN4 contributors: mct - updated : 12-12-2013
HGNC name sideroflexin 4
HGNC id 16088
Corresponding disease
MCYTAM macrocytic anemia with mitochondriopathy
Location 10q26.11      Physical location : 120.900.430 - 120.925.204
Synonym name breast cancer resistance marker 1
Synonym symbol(s) BCRM1
DNA
TYPE functioning gene
STRUCTURE 24.80 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1492 - 305 - 2003 14756423
14 - 1400 - 337 - 2003 14756423
  • SFXN4 I1
  • - - 1400 37 337 placenta 2003 14756423
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tricarboxylate/iron carrier motif
  • conserved predicted five-transmembrane-domains structure
  • HOMOLOGY
    interspecies homolog to to mouse sideroflexin4
    Homologene
    FAMILY sideroflexin family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    text localizes to the mitochondrial inner membrane (PMID;
    basic FUNCTION
  • having cation transporter activity
  • required for mitochondrial homeostasis and hematopoiesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCYTAM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS