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FLASH GENE
Symbol SLC17A3 contributors: mct/npt/pgu - updated : 29-04-2011
HGNC name solute carrier family 17 (sodium phosphate), member 3
HGNC id 10931
Location 6p22.2      Physical location : 25.845.329 - 25.874.471
Synonym name
  • Na(+)/PI cotransporter 4
  • sodium/phosphate cotransporter 4
  • Synonym symbol(s) NPT4, NPT3
    DNA
    TYPE functioning gene
    STRUCTURE 29.14 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1808 - 498 - 1997 9149941
    12 - 1574 - 420 - 1997 9149941
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
     liver   highly Homo sapiens
    Urinarykidneytubuleconvoluted tubuleproximal tubulehighly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • phosphate transport protein, Na+ dependent,containing twelve putative transmembrane segments
  • cytosolic N and C termini
  • a motif in the fourth TM domain charcacteristic of the ACS family
  • HOMOLOGY
    Homologene
    FAMILY
  • solute carrier family 17, sodium/phosphate
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text brush border membrane of the proximal tubules in the kidney
    basic FUNCTION
  • may be involved in actively transporting phosphate into cells via Na+ cotransport
  • could be play a role in the regulation of the glucose-6-phosphatase (G6-Pase) complex
  • multispecific organic anion efflux transporter, likely acting as a common secretion route for both drugs and that may play an important role in diuretics-induced hyperuricemia
  • urate efflux transporter on the apical side of human renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate (
  • apical exit pathway for drugs and urate, together with the fact that other multispecific drug efflux transporters such as breast cancer resistance protein (ABCG2) and multidrug resistance protein 4 (ABCC4) also mediate the transport of urate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to high serum uric acid levels
    Variant & Polymorphism other genetic variants significantly associated with uric acid levels
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    metabolismuric acid 
    candidates as novel hyperuricemia drug development targets
    ANIMAL & CELL MODELS