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FLASH GENE
Symbol SSB contributors: mct - updated : 22-02-2008
HGNC name Sjogren syndrome antigen B (autoantigen LA)
HGNC id 11316
Location 2q31.1      Physical location : 170.655.388 - 170.668.569
Synonym name
  • La ribonucleoprotein domain family, member 3
  • SS-B/La protein
  • autoantigen La
  • Synonym symbol(s) LARP3, LA
    DNA
    TYPE functioning gene
    STRUCTURE 13.00 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure RNA binding site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrineneuroendocrinepituitary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one RNA recognition motif
  • a C-terminal domain that contains an atypical RNA recognition motif and a short basic motif (SBM) adjacent to phosphoserine-366
  • HOMOLOGY
    interspecies homolog to murine Ssb
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III
  • can bind to nascent RNA transcripts and has also been postulated to act as an RNA polymerase III (pol III) transcription initiation and termination factor
  • playing an important role in the modulation of PAM expression, possibly by mechanisms that involve a nuclear retention and perhaps a processing of pre-PAM mRNA molecules
  • essential RNA-binding protein implicated in different aspects of RNA metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • cleaved by granzyme B and N-terminal La fragment (27 kD) translocated to the cytoplasm, thus leading to a novel autoantibody production during granzyme B-mediated cytotoxicity
  • CSNK2A1 is responsible for phosphorylation of SSB protein serine-366 and can modulate RPL37 5prime-terminal oligopyrimidine mRNA metabolism
  • interaction with nucleolin (at least in part responsible for nucleolar accumulation of SSB and nonphosphorylated SSB may be involved in ribosome biogenesis)
  • interacting with CCND1 (role of SSB in cell proliferation and CCND1 expression demonstrating for the first time an overexpression of the RNA-binding protein SSB in solid tumors.)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS