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FLASH GENE
Symbol STARD6 contributors: mct - updated : 09-03-2017
HGNC name StAR-related lipid transfer (START) domain containing 6
HGNC id 18066
Location 18q21.2      Physical location : 51.851.062 - 51.880.943
Synonym name
  • START domain containing 6
  • stAR-related lipid transfer protein 6
  • DNA
    TYPE functioning gene
    STRUCTURE 29.88 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 663 - 220 - 2006 18211099
    EXPRESSION
    Rna function STARD6 mRNA to be testis-specific
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus   Homo sapiens
     gangliasensory gangliadorsal root   Homo sapiens
     spinal cord     Homo sapiens
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    Text only in male germ-line cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a START domain
  • a hydrophobic sterol-binding pocket
  • a unique C-terminal extension
  • STARD4, STARD5 and STARD6 have a similar lipid binding pocket specific for sterols (cholesterol in particular), but differing regulation and localization
  • HOMOLOGY
    interspecies homolog to murine Stard6
    Homologene
    FAMILY
  • StAR-related lipid transfer domain proteins family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • exhibits biological and biophysical properties that imply a role in steroidogenesis
  • might play an important role in lipid sensing of the nervous system
  • might have nuclear roles and contribute to subsequent formation of neuroprotective steroids after excitotoxic brain injury
  • testis proteins, FMR1NB, NXF2, MAGEA5, FSIP1, and STARD6, are required for accurate chromosome segregation in tumor cells
  • overexpression of NXF2, FSIP1, and STARD6, in the absence of paclitaxel, increased the generation of multinucleated cells, a hallmark of aberrant mitosis
  • STAR and STARD6 bind cholesterol, but no cholesterol binding could be detected for STARD5
  • playing likely a previously unappreciated role in cholesterol homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS